Document Details

Document Type : Article In Journal 
Document Title :
Granzyme B, Is It a Cause for Clinicopathological Paradox in Medullary Breast Carcinoma?
هل جرانزيم ب سبب فى التضارب الإكلينيكى الباثولوجى في سرطان الثدى النخاعى؟
 
Document Language : English 
Abstract : Medullary carcinoma is famous of lymphoid infiltrate and improved prognosis. Cytotoxic T lymphocyte with positive Granzyme B constitutes a major subset within the infiltrate. The aim was to study Granzyme B expression and medullary carcinoma behavior. Twenty six female patients were admitted at Dr Fakeeh and Al Hayat Hospitals in Jeddah, K.S.A. from March 2004 to January 2007. Sixteen patients were below 45 years and ten were above. Granzyme B was positive in 75% of the first group and 60% in the second group. Granzyme B expression was positive in 62.5% of infiltrating ductal carcinoma with in situ component while it was 80% without in situ. Granzyme B expressed in 100% of medullary carcinoma, and 60% in others (p < 0.001). 4 lymph nodes out of six were affected in the medullary carcinoma while in others it was 18 out of 20 with no significant statistical differences. Granzyme B+ve Cytotoxic T lymphocyte were 100% in medullary carcinoma while Granzyme B+ve tumor cell was 33.3%. The values were 60% and 20% in others. N0 showed 100% +ve Granzyme B, N1 showed 71.4% and N2 showed 50%. Granzyme B, in a way or another is responsible for damaging cancer cells, leading to lost ability to invade lymphatic vessels or to grow in regional lymph nodes. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 16 
Issue Number : 4 
Publishing Year : 1430 AH
2009 AD 
Article Type : Article 
Added Date : Saturday, July 31, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أشرف علي محمد بكرBaker, Ashraf Ali MohamedResearcher ashrafbakr@hotmail.com
محمد صلاح الدين عبدالحميدAbdelHamid, Mohammed SalahEldinResearcher  
سلافة أمين عبدالعزيزAbdelAziz, Solafa AminResearcher  

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